Publications

Manzi, L., Barrow, A. S., Hopper, J. T. S., Kleanthous, C., Robinson, C. V.,  Moses, J.E., and Oldham N.J., Carbene footprinting reveals binding interfaces of a multimeric membrane spanning protein, Angew. Chem. Int. Ed., 2017, Accepted Article.

Jenner M., Kosol, S., Griffiths, D., Prasongpholchai, P., Manzi, L., Barrow, A. S., Moses, J. E., Oldham, N. J., Lewandowski, J. R. and Challis, G. L., Mechanism of Subunit Interaction at Ketosynthase-Dehydratase Junctions in trans-AT Polyketide Synthases, Nat. Chem. Bio., 2017 (accepted for publication).

Smedley, C. J., Barrow, A. S., Spiteri, C., Giel, M.-C., Sharma, P. and Moses, J. E., Frontispiece: Sulfur-Fluoride Exchange (SuFEx)-Mediated Synthesis of Sterically Hindered and Electron-Deficient Secondary and Tertiary Amides via Acyl Fluoride Intermediates, Chem Eur J.2017, 23, 9990-9995.   

Li, S., Wu, P., Moses, J. E. and Sharpless, K. B. Thionyl Tetrafluoride (O=SF4) Adds Another Dimension to SuFEx Click Chemistry: A S-(VI)-Hub, which Sequentially and Flawlessly Accepts Three Discreet, SuFEx-able Modules, Angew. Chem. Int. Ed., 2017, 56, 2903.

Han, L. -C., Stanley, P. A., Wood, P., Bradshaw, T. D. and Moses, J.E., Horner–Wadsworth–Emmons approach to piperlongumine analogues with potent anti-cancer activity, Org. Biomol. Chem., 2016, 14, 7585.

Silverman, S. M., Sharpless, K. B. and Moses, J. E., Click Chemistry Synthesis of [1,2,3]-Triazole Vancomycin Dimers with Potent Activity against MRSA and VRE, Chem. Eur. J., 2016, 23, 79. 

Manzi, L., Barrow, A. S., Scott, D., Layfield, R., Wright, T. G., Moses, J. E. and Oldham, N. J., Carbene Footprinting Accurately Maps Binding Sites in Protein-Ligand and Protein-Protein Interactions, Nat. Commun., 2016, 7, 13288. 

Zhang, E., Tang, J., Li, S., Wu, P., Moses, J. E. and Sharpless, K. B., Chemoselective Synthesis of Polysubstituted Pyridines from Heteroaryl Fluorosulfates, Chem. Eur. J., 201622, 5692. 

Barrow, A. S. and Moses, J. E., Synthesis of Sulfonyl Azides via Lewis Base Activation of Sulfonyl Fluorides and Trimethylsilyl Azide, Synlett, 2016, 27, 1840. 

Bhat, S. V.,  Robinson, D.,   Sharma, P. and Moses, J. E., Synthesis of Oxadiazol-5-imines via the Cyclizative Capture of in situ Generated Cyanamide Ions and Nitrile Oxides, Org. Lett.,  2016, 18, 1100. 

Stanley, P. A., Spiteri, C., Moore, J. C., Barrow, A. S., Sharma, P. and Moses, J. E., Biomimetic Approaches Towards The Synthesis of Complex Dimeric Natural Products, Curr. Pharm. Des., 2016, 22, 1628.

Roe, S., Gunaratnam, M., Spiteri, C., Sharma, P., Alharthy, R. D., Neidle, S. and Moses, J. E., Synthesis and biological evaluation of hybrid acridine-HSP90 ligand conjugates as telomerase inhibitors, Org. Biomol. Chem., 2015, 13, 8500. 

Cousins, A. R. O., Ritson, D., Sharma, P., Stevens, M. F. G., Searle, M. F. and Moses, J. E., Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences, Chem. Commun., 201450, 15202. 

Moore, J. C., Davies, E. S., Walsh, D. A., Sharma, P. and Moses, J. E., Formal Synthesis of Kingianin A based upon a Novel Electrochemically-induced Radical Cation Diels–Alder Reaction, Chem. Commun.,  201450, 12523.

Powell, K. J., Han, L. –C., Sharma, P. and Moses, J. E., Chemoselective Palladium-Catalyzed Cyanation of Alkenyl Halides, Org. Lett., 2014, 16, 2158.

Dempster, S., Harper, S., Moses, J. E. and Dreveny, I., Structural characterisation of the apo-form and NADH binary complex of human lactate dehydrogenase, Acta Crystallographica Section D,  2014, 70, 1484. 

Borreguero, A. M., Carmona, M. S., Sharma, P., Spiteri, C., Martínez-Velencoso, M., Rodríguez, J. F. and Moses, J. E., A novel ‘click-chemistry’ approach to flame retardant polyurethanes. React. Funct, Polym., 2013, 73, 1207. 

Carbone, G., Burnley, J. and Moses, J. E., A catalytic and tert-butoxide ion-mediated amidation of aldehydes with para-nitro azides, Chem. Commun., 2013, 49, 2759.

Burnley, J., Carbone, G. and Moses, J. E., Catalytic Reduction of ortho- and para-Azidonitrobenzenes via tert-Butoxide Ion Mediated Electron Transfer, Synlett,  201324, 652.

Powell, K. J., Sharma, P., Richens, J. L., Davis, B. M., O’Shea, P. and Moses, J. E., Interactions of Marine-Derived gamma-Pyrone Natural Products with Phospholipid Membranes Phys. Chem. Chem. Phys.,  201214, 14489. 

Ritson, D. J. and Moses J. E., A fragment based click chemistry approach towards hybrid G-quadruplex ligands: design, synthesis and biophysical evaluation, Tetrahedron,  2012, 7, 197.

Awaad, A. S., Al-Jaber, N. A., Moses, J. E., El-Meligy, R. M. and Zain, M. E., Antiulcerogenic Activities of the Extracts and Isolated Flavonoids of Euphorbia cuneata Vahl, Phytother. Res., 201327, 126.

Spiteri, C. and Moses, J. E., Continuous Flow Synthesis of Secondary Amides by Tandem Azidation-Amidation of Anilines, Synlett, 201223, 1546.

Awaad A. S., Al-Jaber N. A., Soliman, G. A., Al-Outhman M. R., Zain M. E., Moses J. E. and El-Meligy R. M., New Biological Activities of Casimiroa edulis Leaf Extract and Isolated Compounds, Phytother. Res.,  201226, 452.

Sharma, P., Ritson, D. J., Burnley J., and Moses, J. E., A synthetic approach to kingianin A based upon biosynthetic speculation, Chem. Commun., 2011, 47, 10605.

Sharma, P., Moorhouse, A. D., and Moses, J. E., Microwave Enhanced Reaction of Thioacids with Azides in Aqueous Media, Synlett, 2011, 16, 2384.

Spiteri, C., Burnley J., and Moses, J. E., Catalyst-Free Regioselective Hydrostannation of Arynes, Synlett, 2011, 17, 2533.

Sharma, P., Powell, K. J., Burnley,  J., Awaad A. S., and Moses, J. E., Total Synthesis of Polypropionate-Derived γ-Pyrone Natural Products, Synthesis, 2011, 18, 2865.

Ritson, D., Spiteri C., and Moses, J. E., A Silver Mediated One-Step Synthesis of Oxazoles, J. Org. Chem., 2011, 76, 3519.

Moorhouse, A. D., Spiteri, C., Sharma, P., Zloh, M., and Moses, J. E., Targeting glycolysis: a fragment based approach towards bifunctional inhibitors of hLDH-5, Chem. Commun., 2011, 47, 230.

Lombardo, C. M., Martinez, I. S., Haider, S., Gabelica, V., Pauw, E. D., Moses, J. E., and Neidle, S., Structure-based design of selective high-affinity telomeric quadruplex-binding ligands, Chem. Commun., 2010, 46, 9116.

Spiteri, C., Keeling S., and Moses, J. E., New Synthesis of 1-Substituted-1H-indazoles via 1,3-Dipolar Cycloaddition of in situ Generated Nitrile Imines and Benzyne, Org. Lett., 2010, 12, 3368.

Sharma, P., and Moses, J. E., Ethynyldiisopropylsilyl: A New Alkynylsilane Protecting Group and “Click” Linker, Org. Lett., 2010, 12, 2860.

Moses, J. E., Ritson, D. J., Zhang, F., Lombardo, C. M., Haider, S., Oldham, N., and Neidle, S., A click chemistry approach to C-3 symmetric G-quadruplex stabilising ligands, Org. Biomol. Chem., 2010, 8, 2926.

Roe, S., Ritson, D. J., Garner, T., Searle, M., and Moses, J. E., Tuneable DNA-based asymmetric catalysis using a G-quadruplex supramolecular assembly, Chem. Commun., 2010, 46, 4309.

Spiteri, C., Mason, C., Zhang, F., Ritson,  D. J., Sharma, P., Keeling, S., and Moses, J. E., An efficient entry to 1,2-benzisoxazoles via 1,3-dipolar cycloaddition of in situ generated nitrile oxides and benzyne, Org. Biomol. Chem., 20108,  2537.

Spiteri, C., Sharma, P., Zhang, F., MacDonald, S. J. F., Keeling, S., and Moses, J. E., An improved synthesis of 1,2-benzisoxazoles: TBAF mediated 1,3-dipolar cycloaddition of nitrile oxides and benzyne, Chem. Commun., 2010, 46, 1272.

Sharma, P., and Moses, J. E., Photochemical Studies of the Tridachiahydropyrones in Seawater, Professor Gerry Pattenden 70th Birthday Special Edition, Synlett, 2010, 4, 525.

Spiteri, C., and Moses, J. E., Copper-Catalyzed Azide-Alkyne Cycloaddition: Regioselective Synthesis of 1,4,5-Trisubstituted 1,2,3-Triazoles, Angew. Chem. Int. Ed., 2010, 49, 31.

Moses, J. E., Rueping, M., and Cronin, L., Highlights from the 44th EUCHEM Conference on Stereochemistry, Bürgenstock, Switzerland, May 2009, Chem. Commun., 2009, 6125.

Garner, T. P., Williams, H. E. L., Gluszyk, K. I., Roe, S., Oldham, N. J., Stevens, M. F. G., Moses J. E., and Searle, M. S., Selectivity of small molecule ligands for parallel and anti-parallel DNA G-Quadruplex structures, Org. Biomol. Chem., 20097, 4194.

Sharma, P., Lygo, B., Lewis, W., and Moses, J. E., Biomimetic Synthesis and Structural Reassignment of the Tridachiahydropyrones, J. Am. Chem. Soc., 2009, 131, 5966.

Gunaratnam, M., Green, C., Moreira, B. J., Moorhouse, A. D., Kelland, L. R., Moses J. E., and Neidle, S., G-Quadruplex compounds and cisplatin act synergistically to inhibit cancer cell growth in vitro and in vivo, Biochem. Pharmacy., 2009, 78, 115.

Zhang, F., and Moses, J. E., Benzyne Click Chemistry With in Situ Generated Aromatic Azides, Org. Lett., 2009, 11, 1587.

Sharma, P., Griffiths, N., and Moses, J. E., Biomimetic Synthesis and Structural Revision of (±)-Tridachiahydropyrone, Org. Lett., 2008, 10, 4025.

Moorhouse, A. D., and Moses, J. E., Microwave Enhancement of a ‘One Pot’ Tandem Azidation-‘Click’ Cycloaddition of Anilines, Synlett, 2008, 14, 2089.

Eade, S. J., Walter, M. W., Byrne, C., Odell, B., Rodriguez, R., Baldwin, J. E., Adlington, R. M., and Moses, J. E., Biomimetic Synthesis of Pyrone-Derived Natural Products: Exploring Chemical Pathways from a Unique Polyketide Precursor, J. Org. Chem., 2008, 73, 4830.

Moorhouse, A. D., Haider, S., Gunaratnam, M., Munnur, D., Neidle, S., and, Moses, J. E., Targeting Telomerase and Telomeres: a Click Chemistry approach towards highly selective G-Quadruplex Ligands, Mol. BioSyst., 2008, 4, 629.

Moorhouse, A. D., and Moses, J. E., Click Chemistry and Medicinal Chemistry: A Case of “Cyclo-Addiction”, ChemMedChem., 2008, 3, 715.

Barral, K., Moorhouse, A. D., and Moses, J. E., Efficient Conversion of Aromatic Amines into Azides: A One Pot Synthesis of Triazole Linkages, Org. Lett., 2007, 9, 1809.

Moses J. E., and Moorhouse, A. D., The Growing Applications of Click Chemistry, Chem. Soc. Rev., 2007, 36, 1249.

Rodriguez, R., Adlington, R. M., Walter, M. W., Baldwin, J. E., and Moses, J. E., Total synthesis of cyercene A and the biomimetic synthesis of (±)-9,10-Deoxytridachione and (±)-Ocellapyrone A, Tetrahedron,  2007, 63, 4500.

Moorhouse, A. D., Santos, A. M., Gunaratnam, M., Neidle, S., and Moses, J. E., Stabilisation of G-Quadruplex DNA by Highly Selectrive Ligands via Click Chemistry, J. Am. Chem. Soc., 2006, 128, 15972.

Comméiras, L., Moses, J. E., Adlington, R. M., Baldwin, J. E., Cowley, A. R., Baker, C. M., Albrecht, B., and Grant, G. H., Total synthesis of the epoxyquinol dimer (+)-panepophenanthrin: application of a diastereospecific biomimetic Diels-Alder dimerisation, Tetrahedron, 2006, 62, 9892.

Moses, J. E., and Adlington, R. M., Sir Jack Baldwin, FRS: Biomimetic Studies at Oxford, Chem. Commun., 2005, 48, 5945.

Moses, J. E., Adlington, R. M., Rodriguez, R., Eade, S. J., and Baldwin, J. E., Biomimetic Synthesis of (±)-9,10-deoxytridachione, Chem. Commun., 2005, 13, 1687.

Jacobsen, M. F., Moses, J. E., Adlington, R. M., and Baldwin, J. E., The biomimetic synthesis of SNF4435C and SNF4435D, and the total synthesis of the polyene metabolites Aaureothin, N-acetyl-aureothamine and spectinabilin, Tetrahedron, 2006, 62, 1675.

Rodriguez, R., Moses, J. E., Adlington, R. M., and Baldwin, J. E., A new and efficient method for o-quinone methide intermediate generation: application to the biomimetic synthesis of the benzopyran derived natural products (±)-Lucidene and (±)-Alboatrin, Org. Biomol. Chem., 2005, 3, 3488.

Jacobsen, M. F., Moses, J. E., Adlington, R. M., and Baldwin, J. E., The Total Synthesis of Spectinabilin and Its Biomimetic Conversion to SNF4435C and SNF4435D, Org. Lett., 2005, 7, 2473.

Jacobsen, M. F., Moses, J. E., Adlington R. M., and Baldwin, J. E., A Short Total Synthesis of Aureothin and N-Acetylaureothamine, Org. Lett., 2005, 7, 641.

Rodriguez, R., Adlington, R. M., Moses, J. E., Cowley, A., and Baldwin, J. E., A New and Efficient Method for o-Quinone Methide Intermediate Generation: Application to the Biomimetic Synthesis of (±)-Alboatrin, Org. Lett., 2004, 6, 3617.

Moses, J. E.,Baldwin, J. E., and Adlington, R. M., An efficient synthesis of cyercene A, Tetrahedron Lett., 2004, 45, 6447.

Moses, J. E., Baldwin, J. E., Brückner, S., Eade, S. J., and Adlington, R. M., Biomimetic studies on polyenes, Org. Biomol. Chem., 2003, 1, 3670.

Brückner, S., Baldwin, J. E., Moses, J. E., and Adlington, R. M., Mechanistic evidence supporting the biosynthesis of photodeoxytridachione, Tetrahedron Lett., 2003, 44, 7471.

Moses, J. E., Baldwin, J. E., Adlington, R. M., Cowley, A. R., and Marquez, R., Thermally induced cascade pericyclic reaction pathways from tetraene esters, Tetrahedron Lett., 2003, 44, 6625.

Moses, J. E., Commeiras, L., Baldwin, J. E., and Adlington, R. M., Total Synthesis of Panepophenanthrin, Org. Lett., 2003, 5, 2987.

Son, A. J. R., Schweiger, S. W., Thorn, M. G., Moses, J. E., Fanwick, P. E., and Rothwell, I. P., The isolation and chemistry of tantalum dimethylamides containing resolved 3,3’-disubstituted-1,1’-bi-2,2’-napthoxide Ligands, Dalton Trans., 2003, 8, 1620.

Moses, J. E., Baldwin, J. E., Marquez, R., Adlington, R. M., Claridge T. D. W., and Odell, B., Biomimetic Synthesis of the Crispatene Core, Org. Lett., 2003, 5, 661.

Moses, J. E., Baldwin, J. E., Marquez, R., Adlington, R. M., and Cowley, A. R., Studies on the Biomimetic Synthesis of SNF4435 C and D, Org. Lett., 2002, 4, 3731.

Thorn, M. G., Moses, J. E., Fanwick, P. E., and Rothwell, I. P., New tantalum compounds supported by 3,3’-disubstituted-1,1’-bi-2-napthoxide ligation, Dalton Trans., 2000, 16, 2659.